Kangming Chen

This paper optimizes saRNA platforms for enhanced protein expression and organ-specific targeting, identifying three alphavirus-derived constructs with improved performance in vivo.

This study uses synthetic genomes to investigate how synonymous codon recoding affects organismal fitness and develops a workflow to overcome lethal effects of codon swaps.

The paper demonstrates a genetic code reassignment strategy that makes cells resistant to viral infections and prevents horizontal gene transfer by mistranslating viral proteins and relying on synthetic codons.