Aromatic Patch in WhiB-Like Transcription Factors Facilitates Primary Sigma Factor Interaction in Mycobacterium tuberculosis
Daisy Guiza Beltran, Tao Wan, Javier Seravalli, Magdaléna Horová, Camden Jones, Shanren Li, Pengchong Ma, Chloe Ong, Zhifang Lu, Donald Becker, Jeffrey P. Mower, Qiuming Yao, Yu Pan, Hongfeng Yu, Adrie J. C. Steyn, Limei Zhang
This study identifies an aromatic patch in Mtb Wbl proteins that mediates interaction with the primary sigma 70 factor, revealing a conserved binding mechanism and evolutionary relationship with actinobacterial phages.
Communications Biology · Feb 13, 2026Peer-reviewedBiochemistry