Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures
Rinu Sivarajan, Paul C. Kirchgatterer, Jan Lawrenz, Eszter Tanner-Matiz, Jessica Lindenmayer, Verena Renz, Tapan Joshi, Heike Oberwinkler, Thorsten Walles, Giorgio Fois, Alexander Kleger, Manfred Frick, Jan Münch, Moritz M. Gaidt, Maria R. Steinke, Konstantin M. J. Sparrer
The paper demonstrates that tonic interferons are critical for early antiviral defense in human lung organoid-derived air-liquid interface cultures against HRV16.
bioRxiv · Dec 11, 2025 · PreprintMicrobiology