Alexander Kleger

ViTAMIn-O is an open DL model for organoid differentiation prediction, outperforming existing models and adaptable to various datasets and imaging modalities.

This study develops human iPSC-derived microvascular models to study diabetic microvascular pathology and identifies inflammatory pathways involved in vascular damage.

The paper demonstrates that tonic interferons are critical for early antiviral defense in human lung organoid-derived air-liquid interface cultures against HRV16.

This study identifies mevalonate biosynthesis as a therapeutic target and biomarker for gemcitabine-resistant pancreatic cancer.

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

This study uses patient-derived organoids to predict drug response and track tumor evolution in pancreatic cancer.

This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.

This study combines large-scale GWAS and single-cell epigenomics to identify cell type-specific mechanisms of type 1 diabetes risk.