Jan Münch

This study identifies human histone H1.2 peptide as an antimicrobial agent against Pseudomonas aeruginosa, showing dose- and pH-dependent growth inhibition without cytotoxicity to mammalian cells.

This study identifies the Man-PTS as a receptor for Angicin in streptococci and defines structural features associated with its antimicrobial activity.

The paper identifies a narrow thermodynamic design window for amphipathic peptides to selectively permeabilize viral membranes while sparing host cells, using a physics-driven generative workflow.

The paper demonstrates that tonic interferons are critical for early antiviral defense in human lung organoid-derived air-liquid interface cultures against HRV16.

This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.

This study shows SEVI fibrils have antibacterial activity against urogenital pathogens and are induced by bacterial surface molecules.

The paper investigates how EPI-X4 binds to CXCR4 using simulations and experiments, leading to the design of more potent and safer CXCR4 antagonists.