Author

Tara M. McDonald

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Kiely MorrisiD· 2 shared Marina HoganiD· 2 shared Nora M. ReediD· 2 shared Robert E. HandsakeriD· 2 shared Sabina BerrettaiD· 2 shared Seva KashiniD· 2 shared Steven A. McCarrolliD· 2 shared Won‐Seok LeeiD· 2 shared

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2024-2026 · peak 1/yr

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10 top collaborators · 44 mutual co-author links

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2 shared papersGenetics

Kiely MorrisORCID

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2 papers

Recent·Most cited

GeneticsCellPeer-reviewedOct 1, 2026

Somatic DNA-repeat expansions initiate distinct yet analogous changes in Huntington's disease cortical and striatal neurons

Seva Kashin, Won‐Seok Lee, Tara M. McDonald…·Steven A. McCarroll

This study shows that somatic DNA-repeat expansions in cortical and striatal neurons of Huntington's disease initiate similar pathological changes, but lead to distinct gene expression outcomes.

1 citation

humanDNA methylation

𝕏 PostBluesky

GeneticsbioRxivPreprintMay 17, 2024

Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease

Robert E. Handsaker, Seva Kashin, Nora M. Reed…·Steven A. McCarroll

The paper shows that HTT CAG repeats expand in striatal neurons over time, leading to gene expression changes and neurodegeneration in Huntington disease.

31 citations

humanwhole-genome sequencing

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