Author

Won‐Seok Lee

Broad InstituteORCID 0000-0001-8633-4682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Kiely MorrisiD· 2 shared Marina HoganiD· 2 shared Nora M. ReediD· 2 shared Robert E. HandsakeriD· 2 shared Sabina BerrettaiD· 2 shared Seva KashiniD· 2 shared Steven A. McCarrolliD· 2 shared Tara M. McDonald· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetics

Kiely MorrisORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Somatic DNA-repeat expansions initiate distinct yet analogous changes in Huntington's disease cortical and striatal neurons

Seva Kashin, Won‐Seok Lee, Tara M. McDonald, Kiely Morris, Robert E. Handsaker, Curtis J. Mello, Liv Spina, Nora M. Reed, Heather de Rivera, Sri Havya Jana, Marina Hogan, Sabina Berretta, Steven A. McCarroll

This study shows that somatic DNA-repeat expansions in cortical and striatal neurons of Huntington's disease initiate similar pathological changes, but lead to distinct gene expression outcomes.

Cell · Oct 1, 2026Peer-reviewedGenetics

Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease

Robert E. Handsaker, Seva Kashin, Nora M. Reed, Steven Tan, Won‐Seok Lee, Tara M. McDonald, Kiely Morris, Nolan Kamitaki, Christopher D. Mullally, Neda R. Morakabati, Melissa Goldman, Gabriel Lind, Rhea Kohli, Elisabeth S. Lawton, Marina Hogan, , Steven A. McCarroll

The paper shows that HTT CAG repeats expand in striatal neurons over time, leading to gene expression changes and neurodegeneration in Huntington disease.

bioRxiv · May 17, 2024 · PreprintGenetics

Literature-based predictions of treatments for genetic disease pathology

Cole A. Deisseroth, Won‐Seok Lee, Ji‐Yoen Kim, Hyun-Hwan Jeong, Julia Wang, Huda Yahya Zoghbi, Zhandong Liu

This paper introduces PARMESAN, a tool that predicts drug-gene relationships using PubMed data, showing high accuracy for top-scoring predictions.

bioRxiv · Sep 8, 2022 · PreprintBioinformatics