Author
McLean HospitalORCID 0009-0001-9646-5122Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Seva Kashin, Won‐Seok Lee, Tara M. McDonald…·Steven A. McCarroll
This study shows that somatic DNA-repeat expansions in cortical and striatal neurons of Huntington's disease initiate similar pathological changes, but lead to distinct gene expression outcomes.
Robert E. Handsaker, Seva Kashin, Nora M. Reed…·Steven A. McCarroll
The paper shows that HTT CAG repeats expand in striatal neurons over time, leading to gene expression changes and neurodegeneration in Huntington disease.
Emi Ling, James C. Nemesh, Melissa Goldman…·Steven A. McCarroll
The paper identifies a neuron-astrocyte gene expression program, SNAP, that declines in aging and schizophrenia, linking it to cognitive function and genetic risk factors.