Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes
Ulrike Fuchs, Sophie Schroeder, Tonatiuh Peña, Dennis M Krueger, Susanne Burkhardt, Anna-Lena Schuetz, Nina Hempel, Verena Gisa, Tarannom Taghavi, Jonathan Cortes, Michael Gertig, Ivana Delalle, Farahnaz Sananbenesi, André Fischer
This study identifies SOX1-OT as a lncRNA that regulates p53-dependent cell-cycle arrest in astrocytes, with implications for Alzheimer's disease.
bioRxiv · Jul 3, 2026 · PreprintNeuroscience