André Fischer

This study shows that miR-223 improves cognitive function and reduces amyloid beta plaques in an Alzheimer's mouse model by enhancing microglial clearance.

The paper identifies Gm16685/MITA1 as a lncRNA that regulates astrocyte reactivity through PCBP2-mediated modulation of IKKβ signaling in inflammatory conditions.

This study identifies SOX1-OT as a lncRNA that regulates p53-dependent cell-cycle arrest in astrocytes, with implications for Alzheimer's disease.

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

This study integrates bulk and single-cell transcriptomics with network modeling to reveal immune networks and lncRNA remodeling in Alzheimer's disease across brain regions.

This study performs a systematic review and transcriptomic meta-analysis of environmental enrichment in rodents, identifying core molecular programs associated with brain plasticity.

This paper identifies a lncRNA, 3222401L13Rik/ENSG00000272070, that modulates microglial inflammatory responses through interaction with PU.1 and is reduced in Alzheimer's disease brains.

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

The paper develops pathway-specific polygenic scores to predict lithium treatment response in bipolar disorder and finds associations with specific biological pathways.

This study identifies two clusters of severe mental disorder patients with differing illness severity, finding elevated pro-inflammatory serum proteins in the more severe group.

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

This study identifies miR-129-5p as a deregulated microRNA in FTD patients, showing its role in astrocyte dysfunction and neurodegeneration.

This study investigates the role of m6A RNA modification in synaptic function and ageing using a mouse model of synucleinopathy, finding age-related changes in m6A methylation of synaptic genes.

The paper identifies Pantr1 as a lncRNA regulated by FOXG1 that facilitates FOXG1's site-specific chromatin binding and impacts neuronal development.

This study identifies 3222401L13Rik as an aging-upregulated lncRNA in astrocytes that enhances neuronal support through interaction with Npas3, suggesting it may delay age-related cognitive decline.

This study identifies PRDM16-DT as an astrocyte-specific lncRNA downregulated in Alzheimer's disease, showing its role in maintaining astrocyte function and neuronal support.

This study analyzes single-cell transcriptomes of the mouse hippocampus after voluntary exercise, identifying molecular changes related to neurogenesis and signaling pathways.

The paper presents a multi-omics dataset for genetic subtypes of frontotemporal dementia to identify molecular mechanisms disrupted in the disease.

The paper identifies a novel miR-99b-5p-Zbp1 pathway in microglia that contributes to schizophrenia pathogenesis and suggests potential therapeutic strategies.

This study shows neuronal extracellular vesicles transfer microRNAs to mediate BDNF-dependent dendritogenesis and synapse maturation in hippocampal neurons.

The paper uses multi-omics data to show FOXG1 regulates transcription and epigenetic processes in mouse hippocampal neurons, working with NEUROD1 to control synaptogenesis.

The paper examines m6A RNA methylation changes in mouse and human brains during aging and Alzheimer's disease, finding reduced m6A levels in synaptic transcripts and impaired synaptic protein synthesis.

The paper shows H3K9ac increases basal progenitor proliferation and neocortex size by upregulating TRNP1 in evolution.

This study shows that SETD1B is crucial for learning and regulates neuronal plasticity genes in the postnatal brain through H3K4me3 modification.

The paper isolates synaptic RNA from hippocampal neurons and identifies microRNAs that regulate the synaptic mRNAome, suggesting astrocytic contribution and dynamic regulation.

This study shows heart failure causes hippocampal gene-expression changes leading to memory impairment in mice, and suggests a drug to improve cognition in heart failure patients.

The paper shows that Setd1b regulates neuronal identity genes in the adult brain, affecting cognitive function and memory, with other KMTs compensating for its absence.

This study identifies age-related downregulation of CHST3 gene expression in the aging mouse brain, linked to epigenetic changes and cognitive decline.

The paper shows that environmental enrichment in adult male mice enhances synaptic plasticity, which is inherited by offspring via sperm RNA, specifically microRNAs 212/132.