Farahnaz Sananbenesi

The lncRNA Gm16685/MITA1 modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signaling

The paper identifies Gm16685/MITA1 as a lncRNA that regulates astrocyte reactivity through PCBP2-mediated modulation of IKKβ signaling in inflammatory conditions.

Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes

This study identifies SOX1-OT as a lncRNA that regulates p53-dependent cell-cycle arrest in astrocytes, with implications for Alzheimer's disease.

Multi-scale transcriptomic integration reveals cell-type immune networks and lncRNA remodeling in Alzheimers disease

This study integrates bulk and single-cell transcriptomics with network modeling to reveal immune networks and lncRNA remodeling in Alzheimer's disease across brain regions.

lncRNA 3222401L13Rik/ENSG00000272070 modulates microglial inflammatory programs in association with PU.1

This paper identifies a lncRNA, 3222401L13Rik/ENSG00000272070, that modulates microglial inflammatory responses through interaction with PU.1 and is reduced in Alzheimer's disease brains.

Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

This study identifies two clusters of severe mental disorder patients with differing illness severity, finding elevated pro-inflammatory serum proteins in the more severe group.

NeuID, a novel neuron-specific lncRNA, resolved a key epigenetic mechanisms linking gene silencing to Alzheimer's disease

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

A role for astrocytic miR-129-5p in Frontotemporal Dementia

This study identifies miR-129-5p as a deregulated microRNA in FTD patients, showing its role in astrocyte dysfunction and neurodegeneration.

LncRNA 3222401L13Rik Is Up-regulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3

This study identifies 3222401L13Rik as an aging-upregulated lncRNA in astrocytes that enhances neuronal support through interaction with Npas3, suggesting it may delay age-related cognitive decline.

PRDM16-DT is a Brain and Astrocyte-Specific lncRNA Implicated in Alzheimers Disease

This study identifies PRDM16-DT as an astrocyte-specific lncRNA downregulated in Alzheimer's disease, showing its role in maintaining astrocyte function and neuronal support.

A novel miR-99b-5p-Zbp1 pathway in microglia contributes to the pathogenesis of schizophrenia

The paper identifies a novel miR-99b-5p-Zbp1 pathway in microglia that contributes to schizophrenia pathogenesis and suggests potential therapeutic strategies.

Epigenetic gene-expression links heart failure to memory impairment

This study shows heart failure causes hippocampal gene-expression changes leading to memory impairment in mice, and suggests a drug to improve cognition in heart failure patients.