Ivana Delalle

This study shows that miR-223 improves cognitive function and reduces amyloid beta plaques in an Alzheimer's mouse model by enhancing microglial clearance.

This study identifies SOX1-OT as a lncRNA that regulates p53-dependent cell-cycle arrest in astrocytes, with implications for Alzheimer's disease.

This paper identifies a lncRNA, 3222401L13Rik/ENSG00000272070, that modulates microglial inflammatory responses through interaction with PU.1 and is reduced in Alzheimer's disease brains.

HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

This study identifies PRDM16-DT as an astrocyte-specific lncRNA downregulated in Alzheimer's disease, showing its role in maintaining astrocyte function and neuronal support.

The paper identifies a novel miR-99b-5p-Zbp1 pathway in microglia that contributes to schizophrenia pathogenesis and suggests potential therapeutic strategies.

The paper examines m6A RNA methylation changes in mouse and human brains during aging and Alzheimer's disease, finding reduced m6A levels in synaptic transcripts and impaired synaptic protein synthesis.

This study maps Aβ deposition in a mouse model and postmortem human tissue, showing subcortical structures are early and vulnerable to Aβ accumulation and network spread.