Ca2+-driven PDIA6 phase separation to ensure proinsulin quality control
Young-Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Katsuya Iuchi, Michiko Tajiri, Kotono Suzuki, Yan Li, Yunseok Heo, Yuka Kamada, Kenta Arai, , Masaki Okumura
This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.
bioRxiv · Jul 30, 2024 · PreprintBiochemistry