Author

Yunseok Heo

Korea Basic Science InstituteORCID 0000-0002-2233-4306Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1

Frequent Co-Authors

Masaki OkumuraiD· 3 shared Shingo KanemuraiD· 2 shared Young‐Ho LeeiD· 2 shared Yuxi LiniD· 2 shared Airu Takeuchi· 1 shared Anh Vu· 1 shared Chanhaeng LeeiD· 1 shared Eiichiro MoriiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Masaki OkumuraORCID

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4 papers

Recent·Most cited

Amyloid fibrils in Alzheimer's disease differently modulate sleep and cortical oscillations in mice depending on the type of amyloid

Tomomi Sanagi, Masaki Okumura, Yuxi Lin, Shingo Kanemura, Eunyoung Moon, Yunseok Heo, Keiko Takahara, Young-Ho Lee, Tomomi Tsunematsu

This study examines how different amyloid-beta fibrils affect sleep and cortical activity in mice, revealing distinct impacts of Aβ40 and Aβ42.

Biophysical Chemistry · Feb 25, 2026Peer-reviewedNeuroscience

Ca2+-driven PDIA6 phase separation to ensure proinsulin quality control

Young‐Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Yuka Kamada, Katsuya Iuchi, Michiko Tajiri, Kotono Suzuki, Yan Li, Yunseok Heo, Kotone Ishii, , Masaki Okumura

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.

Nature Cell Biology · Nov 1, 2025Peer-reviewedBiochemistry

RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning

Lan Thi Trinh, Anh Vu, Seung Ho Shin, Chanhaeng Lee, Sanghee Park, Eun-Bee Cho, Yunseok Heo, Hyun Jin Kim, Sungjoo Kim, Jong‐Bok Yoon

This study identifies RNF13 as a regulator of lysosomal positioning, showing its activity is controlled by pH and Ca2+ levels through interactions with ALG-2 and ARL8B.

Cell Reports · Jul 24, 2025Peer-reviewedCell Biology

Atomistic structure of the interlocking claw-like amyloid fibril of full-length glucagon

Hyeongseop Jeong, Yuxi Lin, Jin Hae Kim, Wookyung Yu, Yunseok Heo, Hyung‐Sik Won, Masaki Okumura, Young‐Ho Lee

The paper reports the atomic structure of glucagon amyloid fibrils using cryo-EM, revealing a dimeric architecture and distinct from previous models.

bioRxiv · Nov 21, 2022 · PreprintMolecular Biology