SCD1 and monounsaturated lipids are required for autophagy and survival of adipocytes
Hiroyuki Mori, Sydney K. Peterson, Rachel C. Simmermon, Katherine A. Overmyer, Akira Nishii, Emma Paulsson, Ziru Li, Annie Jen, Romina María Uranga, Jessica N. Maung, Warren T. Yacawych, Kenneth T. Lewis, Rebecca L. Schill, Taryn A. Hetrick, Ryo Seino, , Ormond A. MacDougald
This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.
Molecular Metabolism · Mar 14, 2024Peer-reviewedMolecular Biology