Ormond A. MacDougald

An Isogenic iPSC Model of LMNA p.R482W Recapitulates Adipocyte Dysfunction in Familial Partial Lipodystrophy Type 2

This paper develops an isogenic iPSC model of FPLD2 carrying the LMNA p.R482W variant, showing adipocyte dysfunction including insulin resistance and metabolic impairment.

Adaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylation

This study shows that cooling reduces protein acetylation in adipocytes, affecting mitochondrial function and metabolism without changing enzyme expression or acetyl-CoA availability.

Teaching adipose tissue as an organ system: addressing weight bias and enhancing anatomical understanding through AdipoAtlas

This study integrates adipose tissue into anatomy education through AdipoAtlas, improving student understanding and perceptions of adipose tissue as a functional organ system.

The Unlabeled Organ: Adipose tissue and normativity in anatomy and physiology texts

This study evaluates how adipose tissue is visually and textually represented in anatomy and physiology textbooks, finding inconsistent framing and terminology use that may hinder its recognition as a dynamic organ system.

Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues

The paper identifies a catecholamine-independent lipolysis pathway activated by hypoglycemia and hypoinsulinemia that enables catabolism of stable adipose tissues.

Control of Physiologic Glucose Homeostasis via the Hypothalamic Modulation of Gluconeogenic Substrate Availability

The paper identifies VMNCckbr neurons that regulate fasting blood glucose by enhancing adipose tissue lipolysis and substrate release via the sympathetic nervous system.

Dietary lipid is largely deposited in skin and rapidly affects insulating properties

The paper shows dietary lipid is deposited in skin, altering its thermal properties and energy regulation within days.

SCD1 and monounsaturated lipids are required for autophagy and survival of adipocytes

This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.

Canonical Wnt Signaling Maintains Human Mesenchymal Progenitor Cell Multipotency During Adipose Tissue Development