Ziru Li

ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection

This study shows ACAN promotes aortic dissection by disrupting mitochondrial homeostasis in VSMCs via the YAP1/TAZ pathway, and its reduction improves disease outcomes.

BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise

BifurcatoR identifies clinically relevant subgroups by analyzing variance patterns in biological data, revealing hidden structures in AML and obesity.

SCD1 and monounsaturated lipids are required for autophagy and survival of adipocytes

This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.