Paternal age affects offspring's behavior possibly via an epigenetic mechanism recruiting a transcriptional repressor REST
Kaichi Yoshizaki, Tasuku Koike, Ryuichi Kimura, Takako Kikkawa, Shinya Oki, Kohei Koike, Kentaro Mochizuki, Hitoshi Inada, Hisato Kobayashi, Yasuhisa Matsui, Tomohiro Kono, Noriko Osumi
The paper shows that paternal age affects offspring behavior through epigenetic changes in sperm DNA methylation, leading to altered gene expression and neuronal abnormalities.
bioRxiv · Feb 15, 2019 · PreprintNeuroscience