Ryuichi Kimura

Self-organized mechanochemical instabilities drive the emergence of digit tissue morphogenesis

The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.

Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice

Advanced paternal age affects vocal development in early postnatal mice, with more pups showing atypical developmental trajectories.

High resolution spatial transcriptome analysis by photo-isolation chemistry

This paper introduces PIC, a method for high-resolution spatial transcriptome analysis, and shows it detects gene expression in small regions of mouse embryos.

Detailed profiles of histone modification in male germ line cells of the young and aged mice

The paper examines changes in histone modifications in male germ line cells of young and aged mice, finding age-related differences in modification intensities, particularly on sex chromosomes.

Paternal age affects offspring's behavior possibly via an epigenetic mechanism recruiting a transcriptional repressor REST

The paper shows that paternal age affects offspring behavior through epigenetic changes in sperm DNA methylation, leading to altered gene expression and neuronal abnormalities.