Noriko Osumi

IntelliProfiler 2.0 is an R pipeline for analyzing RFID tracking data from group-housed mice, capturing circadian and sex-dependent behavioral patterns with improved reproducibility.

This study identifies Kif2C as a critical regulator of radial glial cell integrity, showing its role in preventing cortical malformations and linking its dysfunction to human neurodevelopmental disorders.

The paper predicts post-pubertal social behavior variability in a mouse model of paternal 15q11-13 duplication using neonatal social communication and gene expression data.

IntelliProfiler analyzes multi-animal behavior in home cages using RFID data to quantify locomotion and social interactions, revealing sex, age, and paternal-aging effects on social behavior.

The paper identifies sex-biased transcriptome changes in Pax6 haploinsufficient mouse cortices and highlights Pbdc1 as a candidate regulator of sex-dependent corticogenesis.

This study shows that aging increases ferroptotic vulnerability in round spermatids, leading to a Y-chromosome skew in sperm, which can be modulated by vitamin E.

This study examines age-related changes in mouse sperm miRNA profiles and links them to neurodevelopmental disorders like ASD through target gene analysis.

This study shows Kif23 is essential for proper cytokinesis and neural stem/progenitor cell maintenance in developing mouse and human neocortex, with its disruption leading to microcephaly-like phenotypes.

Advanced paternal age affects vocal development in early postnatal mice, with more pups showing atypical developmental trajectories.

The paper identifies 124 FMRP target genes in murine embryonic neocortex, finds 48 overlapping with autism-related genes, and shows expression changes in four genes in Fmr1-KO mice.

The paper examines changes in histone modifications in male germ line cells of young and aged mice, finding age-related differences in modification intensities, particularly on sex chromosomes.

The paper shows that paternal age affects offspring behavior through epigenetic changes in sperm DNA methylation, leading to altered gene expression and neuronal abnormalities.