A microsporidial deubiquitinase blocks ubiquitin transfer from adenylated E1 to human UBE2K ubiquitin conjugating enzyme
Tomiwa Lawal, Alana H. Chang, Lauren G. Carnley, Nehry Y. Celoge, Taylor A. Blount, Cynthia Vied, Antonia A. Nemec, Robert J. Tomko
The paper identifies ehOTUB1, a microsporidian deubiquitinase that inhibits human UBE2K's ubiquitin conjugation activity by blocking its interaction with the E1 enzyme.
bioRxiv · Jul 31, 2025 · PreprintBiochemistry