Robert J. Tomko

This study identifies Dfm1 as a key factor in Ste24-dependent translocon quality control, showing that its loss increases toxicity of clogged translocon substrates.

This study investigates how the p97/VCP mutation D395G increases redox sensitivity, leading to oxidative inactivation and contributing to neurodegeneration.

The paper identifies ehOTUB1, a microsporidian deubiquitinase that inhibits human UBE2K's ubiquitin conjugation activity by blocking its interaction with the E1 enzyme.