Engineering Large-Scale and Innervated Functional Human Gut for Transplantation
Holly M. Poling, Théo Noël, Akaljot Singh, Garrett W. Fisher, Konrad Thorner, Praneet Chaturvedi, Kalpana Nattamai, Kalpana Srivastava, Matthew R. Batie, Taylor A. Hausfeld, Amy L. Pitstick, Séverine Ménoret, Ignacio Anegón, Riccardo Barrile, Christopher N. Mayhew, , Maxime M. Mahé
This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.
bioRxiv · May 22, 2025 · PreprintBioengineering