Konrad Thorner

Vessel Organoids Reveal FOXF1 Variant-Specific Regulation of Mesoderm and Capillary Development

The paper uses vessel organoids to study how different FOXF1 variants affect mesoderm and capillary development in humans, showing variant-specific disruptions and potential therapeutic rescue.

Single Cell RNA sequencing reveals transitional states and signaling shifts in nephron progenitor cells of the late-gestation rhesus macaque kidney

This study uses single-cell RNA sequencing in rhesus macaques to identify transitional states and signaling shifts in nephron progenitor cells during late gestation, suggesting a mechanism for lateral branch nephrogenesis.

Primitive Hepatoblasts Driving Early Liver Development

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

Engineering Large-Scale and Innervated Functional Human Gut for Transplantation

This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.

Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells

Notch dimerization contributes to maintenance of intestinal homeostasis by a mechanism involving HDAC2.

The paper shows that Notch dimerization is crucial for intestinal homeostasis, with HDAC2 activity modulating Notch function in intestinal stem cells.

The unique function of Runx1 in skeletal muscle differentiation and regeneration is mediated by an ETS interaction domain

This study identifies the unique role of Runx1 in skeletal muscle differentiation and regeneration through its ETS interaction domain, distinguishing it from Runx2.

ELeFHAnt: A supervised machine learning approach for label harmonization and annotation of single cell RNA-seq data

ELeFHAnt harmonizes and annotates single-cell RNA-seq data using ensemble learning methods to integrate multiple references and compare annotations across datasets.