James M. Wells

This study shows that piezoelectric nanofiber scaffolds promote faster spheroid formation and support intestinal organoid development without adverse effects.

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.

This study identifies mesenchymal WNT2B as critical for human intestinal epithelial development and function using patient-derived organoids and transcriptomic analysis.

The paper tests eicosatetraynoic acid (ETYA) in a human intestinal organoid model to suppress pro-fibrotic pathways in macrophages associated with Crohn's Disease.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

This study uses patient-derived organoids to identify new pathologies in individuals with PDX1 mutations, revealing intestinal and gastric metaplasia.

This study identifies a HH-Foxf1-Rspo2 signaling axis critical for tracheal cartilage development and shows its disruption leads to tracheomalacia.

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.

This paper identifies HH/Gli-dependent cellular mechanisms, including endosome-mediated remodeling and matrix degradation, essential for tracheoesophageal separation in mouse and Xenopus embryos.