Stereoselective Covalent Inhibitor of the Ovarian Cancer-Driving Transcription Factor PAX8
Taylor M Nuttall, Aman Modi, Kelvin Li, Emily A. Lau, Alicia Zhang, Bhavna Malik, Tezcan Güney, John E. Eksterowicz, Gregory T. Notte, Thomas J. Maimone, Daniel K. Nomura
This paper develops a stereoselective covalent inhibitor of PAX8, a key ovarian cancer driver, showing its ability to reduce PAX8 abundance and suppress its transcriptional program.
bioRxiv · Aug 21, 2026 · PreprintBiochemistry