Author

Aman Modi

Innovative Genomics InstituteORCID 0000-0002-6174-7189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel K. NomuraiD· 2 shared Emily A. Lau· 2 shared Alicia Zhang· 1 shared Alyssa J. Chew· 1 shared Amy C. Tsao· 1 shared Bhavna Malik· 1 shared Christian E. StiegeriD· 1 shared Claire Song· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Daniel K. NomuraORCID

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2 papers

Recent·Most cited

Stereoselective Covalent Inhibitor of the Ovarian Cancer-Driving Transcription Factor PAX8

Taylor M Nuttall, Aman Modi, Kelvin Li, Emily A. Lau, Alicia Zhang, Bhavna Malik, Tezcan Güney, John E. Eksterowicz, Gregory T. Notte, Thomas J. Maimone, Daniel K. Nomura

This paper develops a stereoselective covalent inhibitor of PAX8, a key ovarian cancer driver, showing its ability to reduce PAX8 abundance and suppress its transcriptional program.

bioRxiv · Aug 21, 2026 · PreprintBiochemistry

An Optimized RNF126-Targeting Covalent Handle for Molecular Glue Degraders

Aman Modi, Ethan S. Toriki, Christian E. Stieger, Emily A. Lau, Claire Song, Alyssa J. Chew, Amy C. Tsao, Kaila Nishikawa, Jeffrey M. McKenna, Daniel K. Nomura

This paper develops an optimized covalent handle targeting RNF126 to create molecular glue degraders, showing improved selectivity and reduced cytotoxicity compared to a fumarate-based handle.

Bioorganic & Medicinal Chemistry Letters · Jul 24, 2026Peer-reviewedBiochemistry