Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling
Isabella P. Gaona, A. Scott McCall, Natalie M. Geis, Arlo C. Colvard, Gianluca T. DiGiovanni, Taylor P. Sherrill, Ujjal K. Singha, David S. Nichols, Ana Paula Moreira Serezani, Holly E. David, Jean‐Philippe Cartailler, Shristi Shrestha, Sergey S Gutor, Timothy S. Blackwell, Jonathan A. Kropski, Jason J. Gokey
This study shows sustained Yap/Taz activation in alveolar epithelial cells leads to fibrotic remodeling and impaired repair, with potential therapeutic implications.
JCI Insight · Jun 9, 2026Peer-reviewedMolecular Biology