Jean‐Philippe Cartailler

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

This study shows that MAFA promotes pancreatic islet maturation by enhancing cell growth, metabolic function, and stress resilience in stem cell-derived islets.

This study shows that MAFB is essential for maintaining adult human α-cell identity and function, linking its downregulation to impaired glucagon secretion and mitochondrial dysfunction in diabetes.

The paper integrates multiple scRNA-seq datasets to create a comprehensive atlas of human pancreatic islets, identifying 13 cell populations and providing a resource for diabetes research.

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

The paper identifies immune cell dysfunction in adipose tissue of individuals with obesity-associated asthma using single-cell RNA sequencing.

This study shows sustained Yap/Taz activation in alveolar epithelial cells leads to fibrotic remodeling and impaired repair, with potential therapeutic implications.

This study shows dehydration increases intracellular lipid synthesis and accumulation by promoting glutamine oxidation and mitochondrial metabolic remodeling.

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

This study characterizes the vascular structure and function of the choroid plexus using multimodal techniques, revealing developmentally distinct endothelial subtypes and mechanosensitive properties.

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

This study shows that warmer temperatures accelerate senescence in mosquitoes by altering transcriptome changes related to immunity, metabolism, and DNA repair.

CelLink integrates single-cell multi-omics data by addressing weak feature linkage and imbalanced cell populations, outperforming existing methods in imputation accuracy and cell subtype annotation.

peakScout translates genomic peak data to gene annotations and vice versa, providing a user-friendly tool for analyzing regulatory element-gene relationships.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

The paper identifies structural features in MAFA and MAFB transcription factors that influence their DNA-binding and Insulin enhancer activity through structural and functional analysis.

The paper develops a knowledge graph framework to extract biomedical knowledge from PubMed, creating a database that enhances transparency in biomedical AI applications.

The paper investigates how photoperiod affects SCN gene expression in mice, identifying key genes and pathways involved in circadian plasticity.

This paper identifies a MAFA S64F variant causing sex-dependent β cell dysfunction and diabetes by accelerating aging and senescence in males.

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.

This study identifies TRAP as essential for insulin biogenesis, showing it facilitates preproinsulin translocation and affects downstream processing and secretion.

iterativeWGCNA improves module detection in WGCNA by iteratively refining gene clusters and minimizing information loss.