Centromeres are hotspots of cytosine methylation epimutations in a filamentous fungus
Mariana Villalba de la Peña, Clayton Hull-Crew, Taylor R Hutter, Cynthia A Vino, Peter Sarkies, Maria Colomé‐Tatché, Frank M. Johannes, Andrew D. Klocko, Ilkka Kronholm
The paper identifies centromeres as hotspots for spontaneous DNA methylation epimutations in Neurospora crassa, showing these changes are mitotically stable and occur much more frequently than genetic mutations.
bioRxiv · Aug 3, 2026 · PreprintGenetics