Peter Sarkies

The paper investigates how gene expression influences genome-wide mutation rates in Drosophila melanogaster and Caenorhabditis elegans, finding that highly expressed genes have lower mutation rates due to transcription-coupled repair.

This study shows ethanol stress increases siRNA-mediated epimutations in fission yeast, leading to transposon expression changes and phenotypic variability.

The paper shows that GTSF-1 binds RRF-3 in nematodes, a conserved interaction essential for 26G-RNA production and fertility.

The paper identifies centromeres as hotspots for spontaneous DNA methylation epimutations in Neurospora crassa, showing these changes are mitotically stable and occur much more frequently than genetic mutations.

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

This study introduces CG methylation in E. coli and finds it increases mutations at CG and AT base pairs, particularly in the absence of AlkB.

This study identifies gene expression variation in genetically identical C. elegans that predicts reproductive traits and shows some variation is causal and influenced by chromatin structure.

The paper investigates the correlation between loss of microRNAs, protein-coding genes, and morphological complexity in syndermatan invertebrates, finding a strong association in regressive evolution.

This study shows that XNP-1, the C. elegans homologue of ATRX, maintains cellular identity by preventing ectopic germline gene expression, and its loss leads to developmental defects.

This study shows that Polycomb-mediated transgenerational epigenetic inheritance in Drosophila eye color does not require small RNAs, but microRNA expression indirectly affects Polycomb complex levels.

The paper develops a bioinformatic pipeline to predict substrates for orphan SLC proteins using multi-omics data, identifying known substrates and new SLC-drug interactions.

This study shows that interchromosomal contacts between regulatory regions can establish stable transgenerational epigenetic inheritance in Drosophila through chromatin interactions mediated by GAGA-factor and Pleiohomeotic.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

This study shows that introducing 5mC into E. coli increases sensitivity to oxidative stress and alkylating agents due to reactive oxygen species and DNA damage.

This study examines the effects of chronic cisplatin exposure on epimutations and tRNA-derived small non-coding RNAs in C. elegans, finding no significant impact on epimutations but increased fluctuations in tRNA-derived RNAs.

The paper investigates the metabolic role of histone methylation in human cells using metabolomics, proteomics, and RNA-seq data, finding that histone methyltransferases are co-regulated by Rb and linked to SAM homeostasis.

The paper shows that chromatin state changes occur spontaneously in C. elegans and can lead to heritable gene expression variation.

This paper demonstrates CRISPR/Cas9-mediated gene editing in the nematode Nippostrongylus brasiliensis using extracellular vesicles to deliver Cas9/guide RNA complexes, achieving targeted gene disruption.

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

The paper identifies that malignancy and NF-kB signalling enhance coordination between mitochondrial and nuclear-encoded oxidative phosphorylation genes in cancer, while healthy tissues show weak or inconsistent coordination.

This study shows that natural selection in C. elegans maintains low TE expression, with increased TE expression observed in smaller populations due to reduced silencing efficiency.

The paper identifies unencapsulated miRNAs secreted by Trichinella spiralis muscle stage larvae that may influence host gene expression.

The paper investigates the evolution of DNA methylation patterns across arthropods, finding widespread conservation of exon methylation in specific genes and lineage-specific changes in TE and promoter methylation.

The paper shows that the Integrator complex cleaves nascent piRNA precursors to terminate promoter-proximal Pol II transcription in C. elegans.

This study identifies RPB-9 as essential for piRNA-mediated silencing in C. elegans by promoting transcriptional elongation/termination at piRNA loci.

This study investigates epimutations driven by small RNAs in C. elegans, finding they arise frequently but have limited duration.

This paper identifies a meiosis-specific function of the phosphatase GSP-2 in promoting germ cell immortality through small RNA-mediated genome silencing in C. elegans.

The paper identifies PETISCO as a novel protein complex essential for 21U RNA biogenesis and embryonic viability in C. elegans, revealing its distinct roles from PID-1.

The paper investigates piRNA biogenesis in nematodes, showing that piRNA upstream motifs are derived from snRNA promoter elements and that piRNA production depends on RNA polymerase II pausing and chromatin structure.

The paper sequences and annotates the genome of Parhyale hawaiensis, identifying key genes for development, immunity, and lignocellulose digestion, providing a resource for comparative studies.