Author

Tayma Handal

Shaare Zedek Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Derick G. WansinkiD· 1 shared Elphège Pierre NoraiD· 1 shared Ester Bnaya· 1 shared Fernanda Vargas-RomeroiD· 1 shared Fouad Zahdeh· 1 shared Geoffrey FudenbergiD· 1 shared Henrik Dahl PinholtiD· 1 shared Irié Carel· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Derick G. WansinkORCID

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2 papers

Recent·Most cited

Cohesin bridging as a physical principle of enhancer-promoter communication

Timothy Földes, Karissa L. Hansen, Maxim Imakaev, Henrik Dahl Pinholt, Nezar A. Abdennur, Geoffrey Fudenberg, Irié Carel, Tayma Handal, Fernanda Vargas-Romero, Elphège Pierre Nora, Leonid A. Mirny

This study proposes that cohesin bridging, not spatial proximity, mediates enhancer-promoter communication and develops a model to validate this mechanism through engineered cell systems.

bioRxiv · May 9, 2026 · PreprintMolecular Biology

Deletion of the CTG Expansion in Myotonic Dystrophy Type 1 Reverses DMPK Aberrant Methylation in Human Embryonic Stem Cells but not Affected Myoblasts

Shira Yanovsky‐Dagan, Ester Bnaya, Manar Abu Diab, Tayma Handal, Fouad Zahdeh, Walther J. A. A. van den Broek, Silvina Epsztejn‐Litman, Derick G. Wansink, Rachel Eiges

This study shows that deleting the CTG expansion in DM1 hESCs reverses DMPK methylation and restores SIX5 transcription, but has no effect on affected myoblasts.

bioRxiv · May 8, 2019 · PreprintGenetics