Henrik Dahl Pinholt

Smc5/6 - microtubules binding shapes pericentromeric chromatin

This study shows that Smc5/6 microtubule binding constrains chromatin dynamics and promotes pericentromeric folding in yeast, safeguarding genome stability during mitosis.

Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation

This study uses live-cell imaging to show that enhancer-promoter interactions drive gene activation through transient contacts of ~25-42 nanometers.

Cohesin bridging as a physical principle of enhancer-promoter communication

This study proposes that cohesin bridging, not spatial proximity, mediates enhancer-promoter communication and develops a model to validate this mechanism through engineered cell systems.

Condensin Accelerates Long-Range Intra-Chromosomal Interactions

This study measures chromosomal encounter times in budding yeast using CICI and finds that condensin accelerates long-range intra-chromosomal interactions compared to inter-chromosomal ones.

A protein-DNA surface hydrogel mechanically reinforces the cell nucleus and protects the genome

The paper shows a protein-DNA co-condensate forms a surface hydrogel that mechanically reinforces the nucleus and protects DNA from damage during mechanical stress.