Nuclear Hormone Receptor NHR-49/HNF4α Couples Fertility Regulation to Resource Allocation and Longevity in C. elegans
Sharada Gopal, Amaresh Chaturbedi, Tej Ramachandrula, John OuYang, Rebecca Rodell, Siu Sylvia Lee
This paper identifies NHR-49 as a regulator of oocyte activation and ovulation in C. elegans, linking fertility, resource allocation, and longevity through its role in controlling GSA-1 expression.
bioRxiv · Jul 14, 2025 · PreprintDevelopmental Biology