The paper compares the effects of three different germline mutations on longevity and fat metabolism in C. elegans, finding distinct physiological outcomes.

Nature Communications · Oct 21, 2025Peer-reviewedGenetics

Nuclear Hormone Receptor NHR-49/HNF4α Couples Fertility Regulation to Resource Allocation and Longevity in C. elegans

Sharada Gopal, Amaresh Chaturbedi, Tej Ramachandrula, John OuYang, Rebecca Rodell, Siu Sylvia Lee

This paper identifies NHR-49 as a regulator of oocyte activation and ovulation in C. elegans, linking fertility, resource allocation, and longevity through its role in controlling GSA-1 expression.

bioRxiv · Jul 14, 2025 · PreprintDevelopmental Biology

Sex-specificity of the C. elegans metabolome

Russell N. Burkhardt, Alexander B. Artyukhin, Erin Zucker-Aprison, Brian J. Curtis, Bennett William Fox, Andreas H. Ludewig, Diana Fajardo Palomino, Jintao Luo, Amaresh Chaturbedi, Oishika Panda, Chester J. J. Wrobel, Victor Baumann, Douglas Portman, Siu Sylvia Lee, Ilya Ruvinsky, Frank C. Schroeder

This study identifies sex-specific metabolomic differences in C. elegans, revealing sex-dependent metabolites and their biological roles.

Nature Communications · Jan 19, 2023Peer-reviewedBioinformatics

Locus-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans

Cheng-Lin Frank Li, Mintie Pu, Wenke Wang, Amaresh Chaturbedi, Felicity J. Emerson, Siu Sylvia Lee

This study identifies age-dependent changes in repressive histone marks and repetitive elements in C. elegans, revealing new heterochromatin domains linked to aging.

PLoS Genetics · Sep 10, 2021Peer-reviewedGenomics