SEQUIN multiscale imaging of mammalian central synapses reveals loss of synaptic microconnectivity resulting from diffuse traumatic brain injury
Andrew D. Sauerbeck, Mihika Gangolli, Sydney J. Reitz, Maverick H. Salyards, Samuel Kim, Christopher Hemingway, Maud Gratuze, Tejaswi Makkapati, Martin Kerschensteiner, David M. Holtzman, David L. Brody, Terrance T. Kummer
This paper introduces SEQUIN, a super-resolution imaging workflow for analyzing synapses, and shows synapse loss in traumatic brain injury and Alzheimer's models.
Neuron · May 8, 2020Peer-reviewedNeuroscience