Martin Kerschensteiner

This paper introduces a FACS-based preprocessing workflow for PBMCs that improves scRNA-seq throughput and preserves biological integrity while enabling rare cell enrichment and cross-donor multiplexing.

The paper introduces CHalo reagents that conditionally ligate to HaloTag proteins, enabling light- or enzyme-triggered labeling, protein recruitment control, and enzyme activity recording.

The paper identifies RORγt-expressing dendritic cells as a distinct APC lineage conserved across tissues and species, with functions beyond promoting tolerance.

This study shows that TREM2 deficiency rescues synaptic integration and functional maturation of transplanted neurons in an inflammatory environment.

This paper develops a fluorogenic probe scaffold that retains fluorescent products within cells to improve imaging sensitivity and resolution for quantifying low-turnover biological processes.

The paper develops fluorogenic chemical probes that detect membrane damage without washing steps, enabling in vivo imaging of cell death mechanisms like ferroptosis and necrosis.

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.

This study introduces ALMA, a deep-learning-based tool for automated limb motion analysis in mice, demonstrating its effectiveness in tracking locomotor deficits and detecting abnormalities in neurological disorders.

The paper introduces ATUM-FIB, a hybrid microscopy technique that combines serial sectioning with FIB-SEM to enable targeted ultrastructural analysis at isotropic resolution.

This paper introduces SEQUIN, a super-resolution imaging workflow for analyzing synapses, and shows synapse loss in traumatic brain injury and Alzheimer's models.

The paper shows that single oligodendrocyte loss in mouse cortex triggers precise remyelination and cell replacement, preserving original myelin patterns while creating new internodes on unmyelinated axons.

The paper shows that calcium accumulations in dendritic spines precede their removal by phagocytes in cortical inflammation, and blocking phagocyte activation prevents synapse loss.

The paper introduces a new imaging technique to enhance fluorescent signal in cleared mouse bodies, enabling whole-body visualization of neuronal connectivity and trauma effects.