Andrew D. Sauerbeck

Hyperexcitable but seizure-free: hippocampal network dysfunction in a Wolfram syndrome model

This study investigates hippocampal network dysfunction in a Wolfram syndrome mouse model, finding hyperexcitable neurons without seizures or increased network bursting.

Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease

This study identifies excitatory synapses as primary targets of α-synuclein aggregation in a Parkinson's disease mouse model, revealing spatial and temporal patterns of synaptic vulnerability.

Cornichon Homolog-3 (CNIH3) Modulates Spatial Memory in Female Mice

This study investigates the role of CNIH3 in spatial memory, finding sex-specific effects where CNIH3 deficiency impairs spatial memory in female mice but not males.

Liver inflammation before spinal cord injury worsens neuropathology, hepatic injury, metabolic syndrome and locomotor deficits

SEQUIN multiscale imaging of mammalian central synapses reveals loss of synaptic microconnectivity resulting from diffuse traumatic brain injury

This paper introduces SEQUIN, a super-resolution imaging workflow for analyzing synapses, and shows synapse loss in traumatic brain injury and Alzheimer's models.