Cell BiologyPLoS ONEPeer-reviewed
Fusion of histone variants to Cas9 enhances homology-directed repair
Tomoko Kato-Inui, Gou Takahashi, Terumi Ono, Yuichiro Miyaoka
This study fuses histone variants to Cas9 to enhance homology-directed repair (HDR) while suppressing non-homologous end joining (NHEJ), finding that H2A.1 improves the HDR/NHEJ ratio better than H2A.X.