MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
James A. Watson, Beatrice Alexander-Howden, Theo S. Hall, Martin A. Wear, Finlay McGhie, Gillian Clifford, Hannah Wapenaar, Juan Zou, Adrian Peter Bird, Marcus D. Wilson
This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.
Nature Communications · Apr 17, 2026Peer-reviewedBiochemistry