Author

James A. Watson

Wellcome Centre for Cell BiologyORCID 0000-0002-5691-1829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Assay:structural biology· 1

Frequent Co-Authors

Marcus D. WilsoniD· 2 shared Adrian Peter BirdiD· 1 shared Beatrice Alexander-HowdeniD· 1 shared Finlay McGhieiD· 1 shared Gauri DeákiD· 1 shared Gillian CliffordiD· 1 shared Hannah WapenaariD· 1 shared Hayden BurdettiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Marcus D. WilsonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 17, 2026

MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation

James A. Watson, Beatrice Alexander-Howden, Theo S. Hall…·Marcus D. Wilson

This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.

4 citationstop 3%

ChIP-seqexperimental assay

𝕏 PostBluesky

BiochemistryStructurePeer-reviewedFeb 17, 2026

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin.

Gauri Deák, Hayden Burdett, James A. Watson, Marcus D. Wilson

This study determines the structure of H3.V-H4.V nucleosomes in Trypanosoma brucei and shows how these variants promote nucleosome plasticity in repressed chromatin.

1 citation

structural biologyexperimental assay

𝕏 PostBluesky