Author

Hannah Wapenaar

Wellcome Centre for Cell BiologyORCID 0009-0003-8790-4511Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:ChIP-seq· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Marcus D. WilsoniD· 3 shared Duncan SprouliD· 2 shared Finlay McGhieiD· 2 shared Francesca Taglini· 2 shared Gillian CliffordiD· 2 shared Willow RollsiD· 2 shared Yujie ZhangiD· 2 shared Adrian Peter BirdiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Marcus D. WilsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 31, 2026

Disease mutations in the PWWP domain of DNMT3A affect chromatin recruitment through multiple mechanisms

Hannah Wapenaar, Gillian Clifford, Francesca Taglini…·Marcus D. Wilson

This study examines how mutations in the PWWP domain of DNMT3A affect chromatin recruitment through different mechanisms, leading to distinct disease phenotypes.

DOI 10.64898/2026.08.28.747843

humanChIP-seq

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedApr 17, 2026

MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation

James A. Watson, Beatrice Alexander-Howden, Theo S. Hall…·Marcus D. Wilson

This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.

4 citationstop 3%

ChIP-seqexperimental assay

𝕏 PostBluesky

GeneticsEMBO ReportsPeer-reviewedJan 30, 2024

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

Francesca Taglini, Ioannis Kafetzopoulos, Willow Rolls…·Duncan Sproul

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

20 citations

humanDNA methylation

𝕏 PostBluesky