Author

Theodora Bautu

University of Copenhagen

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Systems Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

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Anouk M. OlthofiD· 1 shared Jesper Qualmann SvejstrupiD· 1 shared Melvin Noé GonzáleziD· 1 shared Nanna Bach Poulsen· 1 shared Nicolás Nieto MorenoiD· 1 shared Simona Cugusi· 1 shared

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1 shared paperSystems Biology

Anouk M. OlthofORCID

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1 paper

Recent·Most cited

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Anouk M. Olthof, Melvin Noé González, Nanna Bach Poulsen, Nicolás Nieto Moreno, Theodora Bautu, Simona Cugusi, Jesper Qualmann Svejstrup

The paper shows that reducing RNA polymerase II levels disrupts transcriptional homeostasis through organized gene expression changes and feedback loops.

bioRxiv · Sep 18, 2025 · PreprintSystems Biology