Epigenetic markers of middle-age: non-linear DNA methylation changes with aging in humans
Akiyoshi Shimura, Kyosuke Yamanishi, Takaya Ishii, Tomoteru Seki, Tsuyoshi Nishiguchi, Bun Aoyama, Therese Santiago, Varun Bhamidipati Dwaraka, Ryan C. Smith, Gen Shinozaki
The paper identifies non-linear DNA methylation patterns with aging, showing peaks or troughs in middle age and linking them to disease onset.
bioRxiv · Aug 14, 2025 · PreprintGenomics