Tomoteru Seki

The paper examines age-related DNA methylation changes in IL-11 and IL-11RA genes, finding inverse U-shaped patterns that suggest non-linear regulation of IL-11 expression and sensitivity across life stages.

The paper identifies non-linear DNA methylation patterns with aging, showing peaks or troughs in middle age and linking them to disease onset.

This study correlates BSEEG scores with delirium-like behavior in mice, showing age-related differences in the relationship between BSEEG and behavioral outcomes.

This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.

This study validates the use of BSEEG in an LPS-induced mouse model of delirium, showing its correlation with behavioral changes and microglial activation.

This study validates the BSEEG method for quantifying post-operative delirium-like states in mice, showing age-related differences in recovery.