Bun Aoyama

The paper identifies brain-peripheral DNA methylation sites (BrESS) that consistently predict brain methylation across tissues, showing they are not linked to disease heritability.

The paper examines age-related DNA methylation changes in IL-11 and IL-11RA genes, finding inverse U-shaped patterns that suggest non-linear regulation of IL-11 expression and sensitivity across life stages.

This study links neuropathic pain and delirium via microglial activation in mice using combined behavioral, electrophysiological, and transcriptomic analyses.

The paper identifies non-linear DNA methylation patterns with aging, showing peaks or troughs in middle age and linking them to disease onset.

This study correlates BSEEG scores with delirium-like behavior in mice, showing age-related differences in the relationship between BSEEG and behavioral outcomes.

This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.

This study validates the use of BSEEG in an LPS-induced mouse model of delirium, showing its correlation with behavioral changes and microglial activation.