Author
University of IowaORCID 0000-0001-6129-2789Unclaimed ORCID profile · follow to get notified of new preprints
13 papers
Recent·Most cited
Shota Nishitani, Shizhong Han, Takaya Ishii…·Gen Shinozaki
The paper identifies brain-peripheral DNA methylation sites (BrESS) that consistently predict brain methylation across tissues, showing they are not linked to disease heritability.
Bun Aoyama, Shota Nishitani, Kyosuke Yamanishi…·Gen Shinozaki
Akiyoshi Shimura, Varun Bhamidipati Dwaraka, Kyosuke Yamanishi…·Gen Shinozaki
The paper examines age-related DNA methylation changes in IL-11 and IL-11RA genes, finding inverse U-shaped patterns that suggest non-linear regulation of IL-11 expression and sensitivity across life stages.
Kyosuke Yamanishi, Riley Merkel, Nathan James Phuong…·Gen Shinozaki
This study links neuropathic pain and delirium via microglial activation in mice using combined behavioral, electrophysiological, and transcriptomic analyses.
Akiyoshi Shimura, Kyosuke Yamanishi, Takaya Ishii…·Gen Shinozaki
The paper identifies non-linear DNA methylation patterns with aging, showing peaks or troughs in middle age and linking them to disease onset.
Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Akiyoshi Shimura…·Gen Shinozaki
This study correlates BSEEG scores with delirium-like behavior in mice, showing age-related differences in the relationship between BSEEG and behavioral outcomes.
Takaya Ishii, Tao Wang, Kazuki Shibata…·Gen Shinozaki
This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.
Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Nipun Gorantla…·Gen Shinozaki
This study validates the use of BSEEG in an LPS-induced mouse model of delirium, showing its correlation with behavioral changes and microglial activation.
Tsuyoshi Nishiguchi, Kazuki Shibata, Kyosuke Yamanishi…·Gen Shinozaki
This study validates the BSEEG method for quantifying post-operative delirium-like states in mice, showing age-related differences in recovery.
Pedro S. Marra, Takehiko Yamanashi, Kaitlyn J. Crutchley…·Gen Shinozaki
This study examines the association between metformin use and DNA methylation profiles in blood samples to explore potential epigenetic mechanisms of aging and longevity.
Takehiko Yamanashi, Kaitlyn J. Crutchley, Nadia E. Wahba…·Gen Shinozaki
This study identifies DNA methylation changes associated with post-operative delirium in neurosurgery patients using genome-wide analysis of blood samples.
Taku Saito, Hiroyuki Toda, Gabrielle N. Duncan…·Gen Shinozaki
The paper identifies DNA methylation differences in blood between delirium patients and non-delirium controls, highlighting immune response and cholinergic synapse pathways.
Taku Saito, Patricia Braun, Sophia Daniel…·Gen Shinozaki
The paper examines DNA methylation changes in neurotrophic genes across aging and delirium using three independent cohorts, finding positive correlations with aging and stronger associations in delirium cases.