Two-Stage CD8+ CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma
Guoshuai Cao, Yifei Hu, Tony Pan, Erting Tang, Nicholas W. Asby, Thomas Althaus, Jun Wan, Peter A. Riedell, Michael Russell Bishop, Justin Paul Kline, Jun Huang
This study identifies two distinct waves of CD8+ CAR T-cell differentiation in DLBCL patients, showing they originate from different precursor populations with distinct phenotypes and ontogenies.
Nature Communications · May 6, 2025Peer-reviewedImmunology