Author

Justin Paul Kline

University of ChicagoORCID 0000-0002-2967-6448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Erting TangiD· 2 shared Guoshuai CaoiD· 2 shared Jun HuangiD· 2 shared Michael Russell BishopiD· 2 shared Nicholas W. AsbyiD· 2 shared Peter A. RiedelliD· 2 shared Yifei HuiD· 2 shared Alan Cooper· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

Erting TangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapy

Vivek Behera, Alexander Guzzetta, Hannah Giba, Ue-Yu Pen, Anna Di Lello, Bipul Pandey, Benjamin A. Doran, Alessandra Esposito, Apameh Pezeshk, Aliya Husain, Christine M. Bestvina, Justin Paul Kline, Marina C. Garassino, Arjun Raman

This study identifies conserved spatial structures in tumors that predict immune response, using a classification framework based on transcriptional covariation.

Cell Reports Medicine · Aug 28, 2026Peer-reviewedCancer Biology

Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Erting Tang, Yifei Hu, Guoshuai Cao, Duy-Thuc Nguyen, Nicholas W. Asby, Nada S. Aboelella, Hanna A. Ruiz, Xiaolei Cai, Wenbo Zhang, Yu Qing Zhao, Lishi Xie, Xiufen Chen, Michael Russell Bishop, Peter A. Riedell, James L. LaBelle, , Jun Huang

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

Cancer Immunology Research · May 8, 2026Peer-reviewedImmunology

Potentiating CAR-T bystander killing by enhanced Fas/FasL signaling mitigates antigen escape in heterogeneous tumors

Matthew Junda Lin, Joanna K Chorazeczewski, Gvantsa Pantsulaia, Alan Cooper, Moah Sohn, Sidorela Reci, Jaime Mateus-Tique, Nicole H. Hirsh, Xin-Ping Xie, Ivan Odak, Rudra Prasad Dutta, Daniel Charytonowicz, Ranjan Upadhyay, Brian D. Brown, Miriam Mérad, , Joshua Brody

This study shows that enhancing Fas/FasL signaling improves CAR-T cell bystander killing against antigen-negative tumor cells, reducing antigen escape and improving therapeutic outcomes.

bioRxiv · Sep 22, 2025 · PreprintImmunology

Two-Stage CD8+ CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma

Guoshuai Cao, Yifei Hu, Tony Pan, Erting Tang, Nicholas W. Asby, Thomas Althaus, Jun Wan, Peter A. Riedell, Michael Russell Bishop, Justin Paul Kline, Jun Huang

This study identifies two distinct waves of CD8+ CAR T-cell differentiation in DLBCL patients, showing they originate from different precursor populations with distinct phenotypes and ontogenies.

Nature Communications · May 6, 2025Peer-reviewedImmunology