Author

Nicholas W. Asby

University of ChicagoORCID 0000-0002-1675-7601Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

Erting TangiD· 3 shared Guoshuai CaoiD· 3 shared Jun HuangiD· 3 shared Duy-Thuc NguyeniD· 2 shared Justin Paul KlineiD· 2 shared Michael Russell BishopiD· 2 shared Peter A. RiedelliD· 2 shared Tony PaniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Erting TangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Erting Tang, Yifei Hu, Guoshuai Cao, Duy-Thuc Nguyen, Nicholas W. Asby, Nada S. Aboelella, Hanna A. Ruiz, Xiaolei Cai, Wenbo Zhang, Yu Qing Zhao, Lishi Xie, Xiufen Chen, Michael Russell Bishop, Peter A. Riedell, James L. LaBelle, , Jun Huang

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

Cancer Immunology Research · May 8, 2026Peer-reviewedImmunology

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity

Xiaolei Cai, Min Chen, Guoshuai Cao, Nicholas W. Asby, Derek Elli, Haley Gula, Vlad I. Nicolaescu, Duy-Thuc Nguyen, Xiaodan Huang, Tanushree Dangi, Ani Solanki, Sara Woessner, Wenbo Zhang, Erting Tang, Lisa R. Volpatti, , Jun Huang

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

bioRxiv · Jan 24, 2026 · PreprintImmunology

Two-Stage CD8+ CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma

Guoshuai Cao, Yifei Hu, Tony Pan, Erting Tang, Nicholas W. Asby, Thomas Althaus, Jun Wan, Peter A. Riedell, Michael Russell Bishop, Justin Paul Kline, Jun Huang

This study identifies two distinct waves of CD8+ CAR T-cell differentiation in DLBCL patients, showing they originate from different precursor populations with distinct phenotypes and ontogenies.

Nature Communications · May 6, 2025Peer-reviewedImmunology